Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
+44 1300 500008
ISSN: 2155-9880
+44 1300 500008
Sarah Eckart
Germany
Research Article
Reduced NGF-Serum Concentrations in Coronary Artery Disease Patients Increase after Coronary Artery Bypass Grafting
Author(s): Stephan Kohler, Sems Malte Tugtekin, Utz Kappert, Manuel Willbring, Sarah Eckart, Rainer Hellweg and Undine E LangStephan Kohler, Sems Malte Tugtekin, Utz Kappert, Manuel Willbring, Sarah Eckart, Rainer Hellweg and Undine E Lang
Background: Coronary Artery Disease (CAD) is the leading cause of death worldwide, but neurological deficits are the most devastating complications of its treatment, Coronary Artery Bypass Surgery (CABG). As Nerve Growth Factor (NGF) has been implicated in the modulation of inflammatory and fibroproliferative mechanisms leading to atherosclerosis as well as in neuroprotection and survival of neurons, the time course of NGF serum concentrations during CABG has been studied. Methods: Twenty-six male patients were scheduled for coronary artery bypass grafting and NGF levels have been measured 1 hour before the operation started and 2, 5 and 120 hours postoperatively. Pre-operation values of NGFs were compared to healthy controls. Results: We found significantly lower NGF serum concentrations in coronary arter.. View More»
DOI:
10.4172/2155-9880.1000228