Lupus: Open Access
Open Access

Satish Kumar Devarapu

Publications

• Review Article
  Update on Immune Mechanisms in Systemic Lupus and Lupus Nephritis
  Author(s): Satish Kumar Devarapu, Hans-Joachim Anders and Khader Valli RupanagudiSatish Kumar Devarapu, Hans-Joachim Anders and Khader Valli Rupanagudi
  
  Lupus nephritis is a frequent complication of systemic lupus erythematosus. Multiple pathological mechanisms attribute to the pathogenesis of lupus nephritis. These mechanisms can be grossly divided into two groups, extrarenal or intrarenal pathways. A variety of genetic variants break immune tolerance to nuclear autoantigens, as evident from the existence of antinuclear antibodies. Furthermore, molecular mimicry of endogenous nucleic acids activating Toll-like receptors trigger antiviral immunity. In this review, we discuss the molecular pathomechanisms of lupus nephritis... View More»
  DOI: 10.35248/2684-1630.16.1.116

  Abstract PDF

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