Journal of Thyroid Disorders & Therapy
Open Access

Satoshi Nishizuka

Publications

• Research Article
  Association between Granulocyte Colonies Stimulating Factor (G-CSF) Production and Leukocytosis in Anaplastic Thyroid Carcinoma
  
  Author(s): Yuki Tomisawa, Satoshi Ogasawara, Masahiro Kojika, Koichi Hoshikawa, Satoshi Nishizuka and Go Wakabayashi Yuki Tomisawa, Satoshi Ogasawara, Masahiro Kojika, Koichi Hoshikawa, Satoshi Nishizuka and Go Wakabayashi
  
  Background: Leukocytosis is an independent prognostic factor for anaplastic thyroid carcinoma (ATC). In the present study, the potential causes of leukocytosis in ATC were analyzed. Methods: This study involved 22 patients with histologic or cytologic evidence of ATC, as well as papillary thyroid carcinoma (PTC), between June 2000 and October 2009. Samples were obtained from ATC patients before treatment. The xMAP serum assay for 17 cytokines [IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, and IL-17, TNF-α, IFN-γ, GM-CSF, G-CSF, MIP-1β, and MCP-1] and IHC from surgical specimens were performed. Results: WBC was ≥ 10000/mm3 in 9 (41%) and G-CSF was ≥ 100 pg/ml in 4 (18%) ATC cases. The G-CSF level showed a positive correlation with the WBC count in ATC cases (r=0.78). Bot.. View More»
  DOI: 10.4172/2167-7948.1000124

  Abstract

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