Journal of Glycobiology
Open Access

Schwalbe B

Publications

• Case Report
  Progress in HIV-Carbohydrate Interactions: Infectivity of CCR5-Tropic HIV-1 is Enhanced by GP120 from CXCR4-Tropic Virus
  Author(s): Schwalbe B, Hauser H and Schreiber M Schwalbe B, Hauser H and Schreiber M
  
  Human immunodeficiency virus type-1 is highly variable and utilizes two independent pathways, one via the CCR5 coreceptor and the other via CXCR4 to enter CD4+ cells. Both virus types can simultaneously be found in HIV-1-infected patients and the shift to a majority of CXCR4-tropic viruses is an indication for the development of AIDS-related symptoms. It is thought that each virus type will infect cells independently using its specific coreceptor pathways. In this short communication we demonstrate that CCR5-tropic HIV-1 is enhanced by the envelope from CXCR4-tropic viruses. This cross-enhancing effect was completely suppressed when the target cells were pretreated with hexadimethrine bromide, suggesting that carbohydrate structures on the cellular membrane play an important role for envelope-dependent enhancement of viral entry. .. View More»
  DOI: 10.4172/2168-958X.1000110

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