Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Seham El-Kassas
Tanzania
Research Article
Expression and Regulation of Cholecystokinin Receptor in the Chicken’s Immune Organs and Cells
Author(s): Seham El-Kassas, Solomon Odemuyiwa, George Hajishengallis, Terry D Connell and Toufic O NasharSeham El-Kassas, Solomon Odemuyiwa, George Hajishengallis, Terry D Connell and Toufic O Nashar
Cholecystokinin (CCK) is a neuropeptide that affects growth rate in chickens by regulating appetite. CCK peptides exert their function by binding to two identified receptors, CCKAR and CCKBR in the GI tract and the brain, respectively, as well as in other organs. In mammals, CCK/CCKAR interactions affect a number of immunological parameters, including regulation of lymphocytes and functioning of monocytes. Thus, food intake and growth can potentially be altered by infection and the resulting inflammatory immune response. It is uncertain, however, whether chicken express CCKAR in immune organs and cells, and, if so, whether CCKAR expression is regulated by pathogen derived inflammatory stimuli. Herein, we identify expression of CCKAR protein in chicken peripheral blood mononuclear cells (PBMC) including monocytes, and expression of the CCKAR gene in PBMC, thymus, bursa, and spleen, in .. View More»
DOI:
10.4172/2155-9899.1000471