Journal of Clinical and Experimental Ophthalmology
Open Access

Shai M Bar-Sela

Publications

• Research Article
  Retinal Toxicity of Intravitreal Melphalan in Albino Rabbits
  Author(s): Shai M Bar-Sela, Shiri Zayit-Soudry, Amir Massarweh, Irit Mane , Ido Perlman and Anat Loewenstein Shai M Bar-Sela, Shiri Zayit-Soudry, Amir Massarweh, Irit Mane , Ido Perlman and Anat Loewenstein
  
  Background: Intravitreal melphalan injections have been used for treating retinoblastoma with vitreous seeds. The aim of this study was to evaluate the safety margins for intravitreal melphalan, using clinical observations, electrophysiological testing and morphological observations. Methods: In this experimental study, 18 albino rabbits, were treated with intravitreal injection of 0.1 ml melphalan solution to the right, experimental eye, and were divided into 4 dose groups: 5 μg (N=4); 15 μg (N=4); 30 μg (N=5); 60 μg (N=5). The left, control eye, of each rabbit was injected with 0.1 ml saline. Clinical examination, electroretinography (ERG) and visual evoked potentials (VEP) were conducted at baseline and periodically throughout the 4-week follow-up. The eyes were then enucleated and the retinas were prepared for histology and glia.. View More»
  DOI: 10.4172/2155-9570.1000707

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