Journal of Proteomics & Bioinformatics
Open Access

Shailendra K Gupta

Publications

• Research Article
  Geraniol and Limonene Interaction with 3-hydroxy-3- methylglutaryl-CoA (HMG-CoA) Reductase for their Role as Cancer Chemo-preventive Agents
  Author(s): Madhumita Pattanayak, P K Seth, Suchi Smita and Shailendra K Gupta Madhumita Pattanayak, P K Seth, Suchi Smita and Shailendra K Gupta
  
  Recent studies have shown that monoterpenes exhibit antitumor activities and suggest that these compounds are a new class of cancer chemo-preventive agents. Limonene, a main constituent of orange and citrus peel oils has been reported to exert antitumor activity against mammary gland, lung, liver, stomach and skin cancers in rodents whereas, geraniol, a principal constituent of Geranium and Ocimum inhibits the growth of human colon cancer cells. Prenylation of proteins is essential for progression of cells into the S phase and involves post-translational covalent attachment of a lipophilic farnesyl or geranylgeranyl isoprenoid group to numerous proteins. Suppression of prenylation of proteins leads to inhibition of DNA synthesis. Further, epidemiologic evidences suggest that suppression of hydrophilic 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase, a key enzyme of.. View More»
  DOI: 10.4172/jpb.1000107

  Abstract PDF

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