Journal of Clinical and Cellular Immunology
Open Access

Shamala Moodley

Publications

• Research Article
  Transplacental Infection of HIV-1 and the Associated Risk Factors In Utero
  Author(s): Shamala MoodleyShamala Moodley
  
  Background: Identifying risk factors in “in utero” transmission of human immunodeficiency virus type 1 (HIV-1) is important when designing preventive interventions. Several lines of evidence suggest that Natural Killer (NK) cells have an important role in antiviral defence. However, the Human Leucocyte Antigen-G (HLA-G) molecules are inhibitory of these cell-mediated immune responses and could, therefore, promote the propagation of HIV-1 infection across the placental interface thus increasing the risk of vertical transmission. Study design: A total of 55 women were enrolled into the study. Tests for viral loads, CD+4 counts, Natural Killer cells, p24 and HLA-G1 expression were performed. Using logistic regression analyses, a study of the risk factors were undertaken. Results: Variables associated with in u.. View More»
  DOI: 10.4172/2155-9899.1000195

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