Journal of Applied Pharmacy
Open Access

Shanmuga Pandiyan

Publications

• Research Article
  Formulation and Evaluation of Floating Osmotic Tablets of Nizatidine
  Author(s): Ramu Bandameedi and Shanmuga Pandiyan Ramu Bandameedi and Shanmuga Pandiyan
  
  This study was conducted to develop floating osmotic tablets of Nizatidine, a H2 receptor antagonist, to release the drug as two distinct pulses separated by a lag time that achieve plasma concentration profiles varying in a circadian rhythm fashion, for the chronotherapy of ulcer. Floating osmotic tablets were developed using effervescence method consisted of three different steps viz, preparation of floating sustained release drug containing tablets followed by time-lagged (4 hrs) coating with hydrophobic rupturable polymer, ethyl cellulose (EC), and finally compression coating with immediate release dose of nizatidine and supporting buoyant layer. Three ratios of Ethyl cellulose to HPMC E15 (32.5:67.5, 50:50, and 67.5:32.5) at three coating levels (5%, 10%, 15%) were used to optimize the lag time (4 hrs). Carbopol 934P, cross povidone and sodium bicarbonate were used in buoyant lay.. View More»
  DOI: 10.4172/1920-4159.1000209

  Abstract PDF

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