Journal of Clinical and Experimental Ophthalmology
Open Access

Shanta Sarfare

Publications

• Research Article
  Biocompatibility of a Synthetic Biopolymer for the Treatment of Rhegmatogenous Retinal Detachment
  Author(s): Shanta Sarfare, Yann Dacquay, Syed Askari, Steven Nusinowitz and Jean-Pierre Hubschman Shanta Sarfare, Yann Dacquay, Syed Askari, Steven Nusinowitz and Jean-Pierre Hubschman
  
  Objective: The aim of this study is to evaluate the retinal safety and toxicity of a novel synthetic biopolymer to be used as a patch to treat rhegmatogenous retinal detachment. Methods: Thirty one adult wild type albino mice were divided in 2 groups. In Group A (n=9) 0.2 μl balanced salt solution (BSS) and in Group B (n=22), 0.2 μl biopolymer was injected in the subretinal space. Trans-scleral subretinal injection was performed in one eye and the fellow eye was used as control. In both groups, in vivo color fundus photography, electroretinogram (ERG), spectral domain optical coherence tomography (SD-OCT) were performed before injection and at days 7 and 14 post-intervention. Histological analysis was performed following euthanization at days 1, 7 and 21 post-injection. Results: The biopolymer was visualized in the subretinal space in vivo by SD-OCT and post-life by histology up.. View More»
  DOI: 10.4172/2155-9570.1000475

  Abstract PDF

Relevant Topics