Journal of Chromatography & Separation Techniques
Open Access

Sharaf El-Din M

Publications

• Research Article
  Selective Methods for Cilostazol Assay in Presence of its Oxidative Degradation Product and Co Formulated Telmisartan Application to Tablet Formulation
  Author(s): Ibrahim F, Sharaf El-Din M and Heba Abd El-Aziz Ibrahim F, Sharaf El-Din M and Heba Abd El-Aziz
  
  A high performance liquid chromatographic method characterized by its rapidness and sensitivity was developed and validated for quantitation of Cilostazol (CIL) and Telmisartan (TEL) in raw material, their synthetic mixture using isocratic technique and monolithic C8 column (3 mm × 4.6 mm i.d., 2 μm pore size highly porous). The mobile phase composed of acetonitrile:0.03 M dihydrogen phosphate buffer (40:60, v/v) at pH 4.5. Quantification was achieved through UV detection at 257 nm using flow rate of 1 mL/min, and Dipyridamole (DIP) was used as internal standard. DIP, CIL, and TEL, retention times were 2.2, 3.9 and 5.1 min. respectively. Peak area ratios of each drug to Dipyridamol internal standard were plotted against concentration of each drug and linear relations were obtained in the range of 0.5-15 μg/mL for CIL 0.25-20 μg /mL for TEL. The method w.. View More»
  DOI: 10.4172/2157-7064.1000335

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