Translational Medicine
Open Access

Shelly Jain

Publications

• Research Article
  Activation of Mitochondrial Apoptosis and Regulation of Ceramide Signalling by COX-2 Inhibitors in Colon Cancer
  Author(s): SN Sanyal*, Shelly Jain, Preety Ghanghas and Chandan Rana SN Sanyal*, Shelly Jain, Preety Ghanghas and Chandan Rana
  
  Bcl-2 family of proteins is implicated in the malignant tumors including colorectal cancer. Activation of Bcl-2 inhibits the pro-apoptotic proteins (Bax and Bad) and regulates many biological processes such as apoptosis, cell proliferation and cell growth. As the mitochondrial enzymes are involved in sphingolipid metabolism, it can regulate ceramide formation and in turn mitochondria play a central role for the regulation of ceramide induced apoptosis. Bcl-2/ BclxL activates sphingosine kinases (SKs), resulting in the accumulation of S1P (sphingosine-1-phosphate), thereby reducing apoptosis. In the present study, the anti-neoplastic effects have been observed of Etoricoxib and Celecoxib, two COX-2 selective non-steroidal anti-inflammatory drugs (NSAIDs), and Diclofenac, a preferential COX-2 inhibitory NSAIDs, in the early stage of colon cancer in rats. These NSAIDs regress the express.. View More»
  DOI: 10.4172/2161-1025.1000159

  Abstract PDF

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