Journal of Clinical & Experimental Dermatology Research
Open Access

Shereen F Gheida

Publications

• Research Article
  Immunohistochemical Expression of c-kit Receptor (CD117) in Two Pigmentary Disorders
  Author(s): Nagwa M Elwan, Amal A El-Ashmawy, Shereen F Gheida and Omnia K Rizk Nagwa M Elwan, Amal A El-Ashmawy, Shereen F Gheida and Omnia K Rizk
  
  Stem Cell Factor (SCF) is generally thought to be an important regulator of melanocyte and mast cell survival, migration and proliferation. The c-kit receptor (CD117) may play a role in many skin disorders with dyspigmentation. The aim of this study was to assess the immunohistochemical expression of CD117 in some pigmentary disorders such as melasma and vitiligo. The study included a total of 40 patients were divided into two groups; melasma group: included (20) patients and vitiligo group: included (20) patients, in addition to a control group which included (20) healthy skin specimens were obtained during plastic operations. The severity of melasma and vitiligo skin lesions were measured by modified melasma and area severity index (MASI) and vitiligo area severity index (VASI) scores respectively. Tissue biopsies were taken from all the participant and stained by haematoxylin and e.. View More»
  DOI: 10.4172/2155-9554.1000190

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