Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Sherief El Rweney
Royal Holloway,
Review Article
Drug Repositioning Network System Using the Power of Network Analysis and Machine Learning to Predict new Indications for the Approved Drugs “Drug Repositioning and Rate the Level of Drug Similarity
Author(s): Sherief El Rweney
Sherief El Rweney
Statement of the Problem: Drug discovery is a lengthy process, taking on average 12 years for the drugs to reach the market –but as Sir James Black OM once said “the best way to discover a new drug is to start with the old one”. As result, this will drive to Drug repositioning concept. Drug Repurposing and repositioning is Finding a new clinical use for an approved drug. There are many factors that can be used to predict new target disease i.e., protein-protein interaction, chemical structure, gene expression and functional genomics, Phenotype and side effect, genetic variation and Machine learning. Protein-protein interaction PPI is Physical contacts with molecular docking between proteins that occur in a cell or in a living organism in vivo. There is Two Alternative Approaches PPI “Binary: yeast two hybrid (Y2H) and co-complex: (TAP-MS)”. Drug .. View More»
DOI:
10.4172/jpb.1000463