Advanced Techniques in Biology & Medicine
Open Access

Shigekazu Murakami

Publications

• Mini Review
  Prospects of Differentiation Therapy for Cancer Stem Cells
  Author(s): Shigekazu Murakami and Fumio Tashiro Shigekazu Murakami and Fumio Tashiro
  
  The subpopulation of cancer stem cells (CSCs) in tumor tissues drives tumorigenesis and causes the infiltration of cancer cells to surrounding tissues. CSCs are considered to induce tumor initiation, progression, and relapse. Conventional chemotherapies eliminate bulk tumors; however, CSCs evade most therapies. We recently showed that differentiation of CSCs in hepatocellular carcinoma diminished malignant phenotypes. The best strategy for CSC-targeting therapy is yet unknown, however, it appears that differentiation therapy would be effective for certain types of tumors. In this review, we discuss the characteristics of CSCs and prospective use of differentiation therapy for cancer stem cells. .. View More»
  DOI: 10.4172/2379-1764.1000144

  Abstract PDF

Relevant Topics