Journal of Hematology & Thromboembolic Diseases
Open Access
ISSN: 2329-8790
+44 1478 350008
ISSN: 2329-8790
+44 1478 350008
Shigeki Takemoto
National Hospital Organization Kumamoto Medical Center,
1-5 Ninomaru, Kumamoto 860-0008
Japan
Review Article
A Lack of Cellular Senescence, Formation of Microenvironment, and Role of Soluble CD30 in Development of Adult T-Cell Leukemia/Lymphoma
Author(s): Ratiorn Pornkuna and Shigeki TakemotoRatiorn Pornkuna and Shigeki Takemoto
Adult T-cell leukemia/lymphoma (ATL) is a highly aggressive leukemia/lymphoma. The long clinical latency and low incidence of ATL indicate that ATL is an age-related disease with genetic changes that are involved in malignant transformation and monoclonal expansion of human T lymphotropic virus type 1 (HTLV-1) infected cells. The question remains as to how the ATL cells acquire monoclonal proliferation rather than undergo senescence. It was implied that aberrant cellular proteins such as p53, JAK-STAT and Bcl-xL were associated with the development of ATL. HTLV-1-infected cells and ATL cells (partial) express CD30. Soluble CD30 (sCD30) may impair the interaction of CD30 ligand+ cells with CD30+ ATL cells. Probably HTLV-1-infected T-cells migrate to the lung due to agerelated changes of pulmonary immune system. Thereafter monoclonal proliferation of infected cells following antigen pre.. View More»
DOI:
10.4172/2329-8790.1000151