Journal of Developing Drugs
Open Access

Shinde Sunita S

Publications

• Research Article
  Design and Development of Fast Dissolving Tablet of Gliclazide
  Author(s): Kamble Sharad K and Shinde Sunita SKamble Sharad K and Shinde Sunita S
  
  In the present study, Gliclazide is a second-generation sulfonyl urea derivative used to treat non-insulin dependent diabetes mellitus. The drug has been classified as class-II drug according to biopharmaceutical classification system having low solubility and high permeability. So, an attempt was made to enhance the solubility of gliclazide by solvent evaporation technique. A significant enhancement of gliclazide dissolution rate will be obtained using by using suitable techniques. In this PVP-k30, polyethylene glycol and soluplus were mixed with the drug in different ratios (1:1, 1:3) and prepare P1, P2, PE1, PE2, S1 and S2 solid dispersion batches. The optimized solid dispersions P1 were further kneaded with suitable proportions of super disintegrants such as; Cross carmellose and Sodium starch glycolate. Dissolution profile will show decrease amount of drug release at specified ti.. View More»
  DOI: 10.4172/2329-6631.1000177

  Abstract PDF

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