Journal of Applied Pharmacy
Open Access

Shino M

Publications

• Research Article
  Effectiveness of Topical Steroid Therapy for Prevention of Regorafenib associated Hand-foot Skin Reaction
  Author(s): Ishikawa H, Hamauchi S, Tanaka R, Shino M and Yamazaki K Ishikawa H, Hamauchi S, Tanaka R, Shino M and Yamazaki K
  
  Introduction: Hand-foot Skin Reaction (HFSR) often hinders completion of Regorafenib therapy. No established prophylaxis exists against multikinase inhibitor-associated HFSR and further improvement of prophylaxis for HFSR is needed. Therefore, we offer multiagent therapy to prevent Regorafenib-associated HFSR comprising topical steroid (0.05% difluprednate) ointment and 20% urea-based cream. Methods: Subjects were unresectable or recurrent colorectal cancer patients who started Regorafenib therapy between May 2013 and March 2014 at the Shizuoka Cancer Center. Electronic medical records were retrospectively examined for HFSR incidence, CTCAE v3.0 grade of severest HFSR, time of HFSR onset, rate of therapy termination, delay and dose reduction. Results: Subjects were 55 patients and median treatment time 7.1 weeks. O.. View More»
  DOI: 10.21065/1920-4159.1000248

  Abstract PDF

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