Pancreatic Disorders & Therapy
Open Access

Shivam Saxena

Publications

• Research Article
  RAN GTPase and Osteopontin in Pancreatic Cancer
  Author(s): Shivam Saxena, Ankit Gandhi, Pei-Wen Lim, Daniel Relles, Konrad Sarosiek, Christopher Kang, Galina Chipitsyna, Jocelyn Sendecki, Charles J Yeo and Hwyda A Shivam Saxena, Ankit Gandhi, Pei-Wen Lim, Daniel Relles, Konrad Sarosiek, Christopher Kang, Galina Chipitsyna, Jocelyn Sendecki, Charles J Yeo and Hwyda A
  
  Introduction: Pancreatic ductal adenocarcinoma (PDA) has the worst prognosis among cancers, mainly due to the high incidence of early metastases. RAN small GTPase (RAN) is a protein that plays physiological roles in the regulation of nuclear transport and microtubule spindle assembly. RAN was recently shown to mediate the invasive functions of the prometastatic protein osteopontin (OPN) in breast cancer cells. We and others have shown previously that high levels of OPN are present in PDA. In this study, we analyzed the expression and correlation of RAN with OPN in human pancreatic lesions, and explored their regulation in PDA cell lines. Methods: Real time PCR was used to analyze RAN and OPN mRNA levels in PDA, adjacent non-malignant, and benign pancreatic tissues. Expression levels were correlated with survival and different clinicopathological parameters using different statistical .. View More»
  DOI: 10.4172/2165-7092.1000113

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