Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Shu-Feng Zhou
Tanzania
Review Article
Toll Like Receptors Play a Role in General Immunity, Eye Infection and Inflammation: Tlrs for Nanodelivery
Author(s): Jagat R. Kanwar, Shu-Feng Zhou, Sneha Gurudevan, Colin J. Barrow and Rupinder K. Kanwar
Jagat R. Kanwar, Shu-Feng Zhou, Sneha Gurudevan, Colin J. Barrow and Rupinder K. Kanwar
Dendritic cells [DCs] are potent antigen presenting cells [APC], which plays a vital role in immune system by detecting and capturing pathogens in the body. DCs perform a pivotal role in induction of T cell response. Regulation of immune response can be achieved by specific antigen [Ag] delivery to DCs. A delivery system that can efficiently target and present Ags to DCs for the purpose of anti-tumour activity is currently a topic of significant research interest. DCs are receiving attention due to their key role in anti cancer host response and due to their adjuvanic property in tumour vaccines. Role of toll like receptors [TLR] in innate immune system and their part in eventual stimulation of adaptive immunity is exploited to develop vaccines. TLR agonists in conjugation with vaccines are shown to increase therapeutic efficacy in some cases. TLRs also play a vital role in protecting.. View More»
DOI:
10.4172/2155-9899.1000114