Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Shuzhen Qi
Hospital for Skin Diseases, Chinese Academy of Medical Sciences,
12 Jiangwangmiao Street, Nanjing, Jiangsu Province, 210042
China
Research Article
Total Glucosides of Paeony in Combination with Mizolastine Decreased Serum Concentrations of Il-17 And Il-25 in Patients with Chronic Autoimmune Urticaria: A 12-Week Study
Author(s): Shuzhen Qi, Shuchang Hu, Min Zhou, Yingxia Gao, Yeli Wu, Zufeng Sun and Qingjie HuShuzhen Qi, Shuchang Hu, Min Zhou, Yingxia Gao, Yeli Wu, Zufeng Sun and Qingjie Hu
Objective: This study investigated total glucosides of paeony (TGP)'s effect on serum IL-17 and IL-25 concentrations in patients with chronic autoimmune urticaria (CAU).Methods: 71 autologous serum skin test (ASST)+CAU patients were randomized into two groups: 35 patients orally received 0.6g TGP t.i.d. plus 10 mg mizolastines once daily for 12 weeks (Treatment Group). The remaining 36 patients orally received 10 mg mizolastines once daily for 12 weeks (Control Group). Additionally, 60 ASSTchronic spontaneous urticaria patients were used for baseline comparison. Serum IL-17 and IL-25 concentrations were measured and compared between the Treatment Group, Control group and the ASST- patients at baseline; they were further measured and compared between the Treatment and Control groups at weeks 4 and 12.Results: Baseline serum.. View More»
DOI:
10.4172/2155-9899.1000570