Immunome Research
Open Access

Silvia Sedda

Publications

• Review Article
  Smad7 as a Target for Immunomodulation Strategy in Inflammatory Bowel Diseases
  Author(s): Silvia Sedda, Edoardo Troncone, Maria Imeneo and Giovanni Monteleone Silvia Sedda, Edoardo Troncone, Maria Imeneo and Giovanni Monteleone
  
  Inflammatory bowel diseases (IBD) are chronic inflammatory pathologies of the gut, characterized by a relapsing-remitting course. Although IBD pathogenesis is not fully understood, epidemiological and experimental data suggest that multiple environmental factors can, in genetically predisposed individuals, trigger an excessive immune response directed against the antigens of the normal intestinal microflora, which eventually leads to the tissue damage. Defects in the physiological mechanisms/factors of counter-regulation contribute to amplify and sustain such a detrimental response. For instance, in inflamed tissue of IBD patients there is diminished activity of the immunesuppressive cytokine transforming growth factor (TGF)-β1, due to elevated levels of Smad7, an intracellular inhibitor of TGF-β1 signaling. Consistently, knockdown of Smad7 with a specific antisense oligonuc.. View More»
  DOI: 10.4172/1745-7580.1000133

  Abstract PDF

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