Journal of Cell Science & Therapy
Open Access

Sima T Tarzami

Publications

• Review Article
  Tumor Necrosis Factor-Alpha and Inflammation-Mediated Cardiac Injury
  Author(s): Edna Howerton and Sima T Tarzami Edna Howerton and Sima T Tarzami
  
  Experimental evidence is accumulating implicating a major role for inflammatory activation in chronic heart failure. Levels of pro-inflammatory protein mediators, such as tumor necrosis factor-alpha (TNF-α), a pro inflammatory cytokine, have been shown to be elevated in heart failure patients and appear to be directly related to pathological changes in the myocardium. Unfortunately, outcomes from clinical trials using anti-cytokine therapies to chronic heart failure patients have been largely disappointing. TNF-α is a pleiotropic cytokine, impacting tissues in a complex manner that regulates many physiological and pathological processes that can trigger differentiation, inflammation, and cell death. TNF-α is important in initiating and regulating the cytokine cascade during an inflammatory response. Most of the studies focused on the TNF-α as an immune mediator.. View More»
  DOI: 10.4172/2157-7013.1000268

  Abstract PDF

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