Entomology, Ornithology & Herpetology: Current Research
Open Access

Simon MK

Publications

• Review Article
  Understanding the Mechanisms Involved in the Regulation of Cytochrome P450 Gene Expression in Drosophila melanogaster (Diptera: Drosophilidae)
  Author(s): Mohammed BR*, Simon MK, Opara MN, Jegede OC, Agbede RIS and Finn RDMohammed BR*, Simon MK, Opara MN, Jegede OC, Agbede RIS and Finn RD
  
  Cytochrome P450 monooxygenases (P450s) are known to play a central role in the adaptive response of insects and other animals to chemicals in the environment. Drosophila spp. P450s are known to be regulated by Cap ‘n’ collar isoform C (CnCC) and/ Spineless (ss) which are orthologs to Nuclear factor erythroid-2 factor 2 (Nrf2)/Aryl hydrocarbon receptor (AhR) in higher mammals. However, the mechanism underpinning this regulation in insects including fruit fly, Drosophila melanogaster is poorly understood. Understanding the constitutive and inducible patterns of expression requires knowledge about the signalling pathways that control insect P450 expression, which is still lacking for most identified insect P450s. D. melanogaster, because of its longstanding use as a genetic model insect, is a powerful tool for identifying possible regulatory mechanisms and for following expre.. View More»
  DOI: 10.4172/2161-0983.1000189

  Abstract PDF

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