Organic Chemistry: Current Research
Open Access

Sirsat Shivraj B

Publications

• Research Article
  Simple and Efficient Synthesis of Novel Fused Bicyclic Heterocycles Pyrimido-Thiazine and Their Derivatives
  Author(s): Sirsat Shivraj B and Vartale Sambhaji P Sirsat Shivraj B and Vartale Sambhaji P
  
  We report simple and efficient synthesis of novel fused bicyclic heterocyclic compounds 3 using bis (methylthio) methylene malononitrile 1 and thiourea 2 with potassium carbonate in DMF at reflux condition. The molar ratios of these substrates are 2:1 for the preparation of 2,6-dihydro-2,6-diimino-4,8-bis(methylthio) pyrimido[2,1-b][1,3]thiazine- 3,7-dicarbonitrile. This newly synthesized pyrimido thiazine acts as bis-electrophilic species reacting with various nucleophiles yielding 2,6-dihydro-2,6-diimino-4,8-(disubstituted)-pyrimido[2,1-b][1,3]thiazine-3,7-dicarbonitrile in good yields. .. View More»
  DOI: 10.4172/2161-0401.1000110

  Abstract PDF

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