Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Sophie Erhardt
Sweden
Research Article
Comparative Proteome Analysis of Thalamus and Cortex from Rats Subchronically Treated with Kynurenine and Probenecid
Author(s): Linda Paulson, Linda K. Nilsson-Todd, Klas R. Linderholm, Ann Brinkmalm, Peter S.Eriksson, Göran Engberg and Sophie ErhardtLinda Paulson, Linda K. Nilsson-Todd, Klas R. Linderholm, Ann Brinkmalm, Peter S.Eriksson, Göran Engberg and Sophie Erhardt
Research focusing on glutamate as a major contributor to schizophrenia has attained increasing prominence over the past decade. Analogous to an NMDA-receptor hypofunction in schizophrenia, growing evidence suggest that the disease is related to an excess of brain kynurenic acid (KYNA), an endogenous antagonist at the glycine-site of the NMDA receptor. Previous studies have shown tha t MK-801, an NMDA-receptor antagonist with psychotomimetic properties, induces alteration of several genes and protein levels in cortex and thalamus previously found to be changed in the brains of patients with schizophrenia. In the present study, we use p roteomics to investigate whether an increased KYNA turnover in the brain, induced by subchronic treatment of kynurenine and probenecid, w ould interfere with the protein synthesis in the cortex and thalamus in the rat brain. The levels of four proteins .. View More»
DOI:
10.4172/jpb.1000014