Journal of Clinical Toxicology
Open Access

Sripriya Sundararajan

Publications

• Research Article
  Toxic Metal Contamination of Banked Blood Designated for Neonatal Transfusion
  Author(s): Sripriya Sundararajan, Allison M Blatz, Dorr G Dearborn, Arthur W Varnes, Cynthia F Bearer and Dina El Metwally Sripriya Sundararajan, Allison M Blatz, Dorr G Dearborn, Arthur W Varnes, Cynthia F Bearer and Dina El Metwally
  
  Objective: Very low birth weight (VLBW) infants frequently receive blood transfusions. We hypothesize that toxic metals in donor blood may pose a health risk with potential adverse neurologic effects on the developing brain of a vulnerable VLBW infant. Study design: Samples from 100 donor blood units were collected from a large urban hospital. Blood was analyzed for aluminum, arsenic, beryllium, cadmium, manganese, mercury, nickel, lead and polonium. The estimated upper limit of acceptable metal concentration in donor blood was calculated assuming a transfusion volume of 20 ml/kg and using either previously published acceptable intravenous doses or oral reference doses with a conservative estimate of 10% gastrointestinal absorption. Ingested mercury was assumed to be 95% absorbed. Results: Eight of the nine metals .. View More»
  DOI: 10.4172/2161-0495.1000267

  Abstract PDF

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