Clinical & Experimental Cardiology
Open Access

Stephanie Matta

Publications

• Research Article
  Prevalence and Predictors of Worsening of Diastolic Function in Cancer Patients with Normal Baseline Ejection Fraction undergoing Chemotherapy
  Author(s): Antoine Abchee, Hadi Skouri, Stephanie Matta, Lara El-Masri, Chadi Alraies and Wael A AlJaroudiAntoine Abchee, Hadi Skouri, Stephanie Matta, Lara El-Masri, Chadi Alraies and Wael A AlJaroudi
  
  Purpose: Chemotherapeutic agents such as anthracyclines and monoclonal antibodies Tyrosine Kinase Inhibitors (TKI) have been associated with systolic and Diastolic Dysfunction (DD). Data from the Middle Eastern region is lacking, and disparities in response to therapy and toxicity profile have been observed among different racial and ethnic groups. We hypothesized that worsening diastolic function proceeded systolic dysfunction among Middle Eastern patients with normal baseline echocardiogram receiving chemotherapy, and sought to assess its incidence and independent predictors. Methods: Consecutive outpatients presenting for baseline echocardiogram prior to chemotherapy were prospectively enrolled between 7/2013 and 6/2014. Patients with EF <50%, severe valvular disease, or atrial fibrillation were excluded. Diastolic function was graded bl.. View More»
  DOI: 10.4172/2155-9880.1000349

  Abstract PDF

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