Anesthesia & Clinical Research
Open Access
ISSN: 2155-6148
ISSN: 2155-6148
Stephen Bottrell
Australia
Research Article
The Impact of Routine Norepinephrine Infusion on Hemodilution and
Blood Transfusion in Cardiac Surgery
Author(s): David J Canty, Martin Kim, Colin F Royse, David T Andrews, Stephen Bottrell and Alistair G Royse
David J Canty, Martin Kim, Colin F Royse, David T Andrews, Stephen Bottrell and Alistair G Royse
Background: Hemodilution and blood transfusion are associated with poor outcome after cardiac surgery. We hypothesized that routine norepinephrine infusion commenced prior to anesthesia induction during on-bypass cardiac surgery would reduce intraoperative hemodilution and red cell transfusion.
Methods: Two cohorts of consecutive cardiac surgery patients at different time periods were retrospectively reviewed for perioperative hemoglobin, creatinine concentrations and units of red cells transfused. Patients in group NE (n=72, in 2010) all received standardized hemodynamic management by a single anesthesiologist with low dose norepinephrine infusion commenced at 3-5 μg.min-1 (18-30 nmol.min-1, 0.24-0.4 nmol.kg-1.min-1) commencing prior to anesthetic induction and continued into the postoperative period. In the absence of blood loss, hemody.. View More»
DOI:
10.4172/2155-6148.1000342