Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Stephen C Foster
Massachusetts Eye Research and Surgery Institution (MERSI),
5 Cambridge Center, 8th Floor, Cambridge, MA 02142
Tanzania
Review Article
Ocular Manifestations of Systemic Lupus Erythematosus
Author(s): Asima Bajwa and Stephen C Foster
Asima Bajwa and Stephen C Foster
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by production of numerous antibodies that may affect multiple organ systems. Wide variety of systemic features of SLE are attributed to antibodies against the components of cell nuclei. Many of the clinical features, like nephritis and arthritis are due to deposition of immune complexes resulting in tissue damage. Other features of the disease such as hemolytic anemia, thrombocytopenia is due to direct effect of autoantibodies. The ocular manifestations of SLE include lid dermatitis, keratitis, scleritis, secondary Sjogrens syndrome, retinal and choroidal vascular lesions and neuroophthalmic lesions. Keratoconjunctivitis sicca is the most common ocular manifestation, but visual morbidity is usually due to retinal and neuro-ophthalmic manifestations of the disease. Ocular involvement may precede systemic onset of.. View More»
DOI:
10.4172/2155-9899.1000191