ISSN: 2155-9570
+44 1223 790975
Steven Nusinowitz
Tanzania
Research Article
Biocompatibility of a Synthetic Biopolymer for the Treatment of Rhegmatogenous Retinal Detachment
Author(s): Shanta Sarfare, Yann Dacquay, Syed Askari, Steven Nusinowitz and Jean-Pierre HubschmanShanta Sarfare, Yann Dacquay, Syed Askari, Steven Nusinowitz and Jean-Pierre Hubschman
Objective: The aim of this study is to evaluate the retinal safety and toxicity of a novel synthetic biopolymer to be used as a patch to treat rhegmatogenous retinal detachment. Methods: Thirty one adult wild type albino mice were divided in 2 groups. In Group A (n=9) 0.2 μl balanced salt solution (BSS) and in Group B (n=22), 0.2 μl biopolymer was injected in the subretinal space. Trans-scleral subretinal injection was performed in one eye and the fellow eye was used as control. In both groups, in vivo color fundus photography, electroretinogram (ERG), spectral domain optical coherence tomography (SD-OCT) were performed before injection and at days 7 and 14 post-intervention. Histological analysis was performed following euthanization at days 1, 7 and 21 post-injection. Results: The biopolymer was visualized in the subretinal space in vivo by SD-OCT and post-life by histology up.. View More»
DOI:
10.4172/2155-9570.1000475