Journal of Clinical and Experimental Ophthalmology
Open Access
ISSN: 2155-9570
ISSN: 2155-9570
Subhasish Pramanik
India
Research Article
Modification of Biochemical Derangements and VEGF Secretion May Prevent Diabetic Retinopathy (DR)
Author(s): Lakshmi Kanta Mondal, Subhasish Pramanik, Sriparna De, Suman K Paine and Gautam BhaduriLakshmi Kanta Mondal, Subhasish Pramanik, Sriparna De, Suman K Paine and Gautam Bhaduri
Unutilized, enormous intracellular glucose in insulin-nondependent tissues, including retina, leads to several consequences: (i) increased formation of advanced glycation end products, (ii) activation of polyol pathway, (iii) anaerobic glycolysis, (iv) glutamate toxicity, (v) lipid peroxidation and oxidative stress, and all of these, finally, resulting in convergence to up regulation of antigenic VEGF and VEGFR2, the crucial player in the development of DR. The purpose of the present pilot study is to assess the effects of one kind of intervention on the development of DR: supplementation of B-vitamins (B1, B2, B3, B5 and B6), vitamin C and vitamin E on amelioration of biochemical derangements related to development of DR.
400 diagnosed type 2 diabetic patients were identified for the study, of which subjects were randomised 1:1 to receive oral antidiabetic medication along wi.. View More»