Journal of Clinical and Cellular Immunology

Journal of Clinical and Cellular Immunology
Open Access

ISSN: 2155-9899

Sunil K. Chauhan

Sunil K. Chauhan
Schepens Eye Research Institute,
20 Staniford Street, Boston, MA 02114
Tanzania

Publications
  • Review Article
    Corneal Lymphatics: Role in Ocular Inflammation as Inducer and Responder of Adaptive Immunity
    Author(s): Sunil K. Chauhan, Thomas H. Dohlman and Reza DanaSunil K. Chauhan, Thomas H. Dohlman and Reza Dana

    The normal cornea is devoid of lymphatic and blood vessels, thus suppressing both the afferent (lymphatic) and efferent (vascular) arms of the immune response–contributing to its ‘immune privilege’. Inflammation, however, negates this unique ‘immune’ and ‘angiogenic’ privilege of the cornea. Abnormal blood vessel growth from pre-existing limbal vessels into the cornea has been studied for many years, but it is only recently that the significance of new lymphatic vessels (lymphangiogenesis) in ocular inflammatory diseases has been demonstrated. Whereas blood vessels in inflamed ocular surface provide a route of entry for immune effector cells to the cornea, lymphatics facilitate the exit of antigen-presenting cells and antigenic material from the cornea to regional lymph nodes, thus promoting induction of adaptive i.. View More»
    DOI: 10.4172/2155-9899.1000256

    Abstract PDF

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