Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Suresh Kumar M
India
Research Article
Structural Epitope Database (SEDB): A Web-based Database for the Epitope, and its Intermolecular Interaction Along with the Tertiary Structure Information
Author(s): Om Prakash Sharma, Arindam Atanu Das, Krishna R, Suresh Kumar M and Premendu P MathurOm Prakash Sharma, Arindam Atanu Das, Krishna R, Suresh Kumar M and Premendu P Mathur
An epitope is an antigenic determinant. It is a part of antigen, which is recognized by specific receptor of the immune system, exclusively by antibodies, B-cells or T-cells. Thus, exhaustive molecular knowledge of epitopes will have great implications for vaccine and drug design. Existing epitope databases are lacking complete structural information of epitopes. Therefore, we have developed an open-access database for describing the three-dimensional structure of epitopes and its interaction with antigens and antibodies. We have cataloged 619 epitope structures from Protein Data Bank and published research articles. Our database provides an extensive collection of B-cell, T-cell and MHC binding proteins. For user convenience, these epitopes have been classified based on structure (Linear epitope and Discontinuous epitope) and cell types (B-cell, T-cell and MHC binding). Our database .. View More»
DOI:
10.4172/jpb.1000217