Immunome Research
Open Access

Susan J Burke

Publications

• Editorial
  Insulitis and Diabetes: A Perspective on Islet Inflammation
  Author(s): Susan J Burke and J Jason CollierSusan J Burke and J Jason Collier
  
  Immune cell infiltration into pancreatic islets (termed insulitis) has been linked with destruction of pancreatic β-cells and thus with onset of diabetes mellitus. Recently published guidelines for reporting insulitis may generate some deliberation on pancreatic islet inflammation and a re-examination of the role that immune cells play in the process of β-cell death and dysfunction. Herein, we offer the viewpoint that a mild insulitis (e.g., 2-fold increase in leukocytic infiltration) would be sufficient to produce an adequate supply of inflammatory molecules capable of initiating and maintaining an inflammatory state within the pancreatic islets. .. View More»
  DOI: 10.4172/1745-7580.S2.e002

  Abstract PDF

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