Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Suthat Liangpunsakul
Tanzania
Research Article
Serum Proteomic Profiles in Subjects with Heavy Alcohol Abuse
Author(s): Suthat Liangpunsakul, Xianyin Lai, Heather N. Ringham, David W. Crabb and Frank A. WitzmannSuthat Liangpunsakul, Xianyin Lai, Heather N. Ringham, David W. Crabb and Frank A. Witzmann
Objectives: The abuse of alcohol is a major public health problem, and the diagnosis and care of patients with alcohol abuse and dependence is hindered by the lack of tests that can detect dangerous levels of drinking or relapse during therapy. Gastroenterologists and other healthcare providers find it very challenging to obtain an accurate alcohol drinking history. We hypothesized that the effects of ethanol on numerous systems may well be reflected in changes in quantity or qualities of constituent or novel plasma proteins or protein fragments. Organ/tissue-specific proteins may be released into the blood stream when cells are injured by alcohol, or when systemic changes are induced by alcohol, and such proteins would be detected using a proteomic approach. The objective of this pilot study was to determine if there are plasma proteome profiles .. View More»
DOI:
10.4172/jpb.1000082