Journal of Cell Science & Therapy
Open Access

Svend Andersen

Publications

• Review Article
  Ethical Perspectives on Stem Cell-based Cellular Therapies for Neurodegenerative Diseases
  Author(s): Mette Ebbesen, Finn Skou Pedersen, Svend Andersen and Thomas G. JensenMette Ebbesen, Finn Skou Pedersen, Svend Andersen and Thomas G. Jensen
  
  The effect of stem cell-based therapies for neurodegenerative diseases such as Alzheimer disease, Huntington disease, and Parkinson disease are currently being investigated. Here we specify possible therapeutic effects and possible side effects for patients and conclude that cellular therapies may have benefits for patients. The side effect described most commonly in the literature is the risk of tumor formation by stem cells not fully differentiated into neurons when transplanted or following viral transduction and subsequent differentiation to create induced pluripotent stem cells. This risk may be avoided by differentiating stem cells in culture before transplantation.   Here we argue that the following ethical considerations are important for clinical trials: Informed consent of research subjects or patients, specification of possible therapeutic effects, risk a.. View More»
  DOI: 10.4172/2157-7013.S3-003

  Abstract PDF

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