Journal of Proteomics & Bioinformatics
Open Access

Svend Birkelund

Publications

• Research Article
  Effect of IL-6R Inhibition with Tocilizumab on the Proteome of Peripheral Blood Mononuclear Cells from a Rheumatoid Arthritis Patient
  Author(s): Michael Kruse Meyer, Marlene Andersen, Tue Bjerg Bennike, Svend Birkelund, Grethe Neumann Andersen and Allan Stensballe Michael Kruse Meyer, Marlene Andersen, Tue Bjerg Bennike, Svend Birkelund, Grethe Neumann Andersen and Allan Stensballe
  
  Objective: The availability of biological disease-modifying anti-rheumatic drugs (bDMARDs) has increased during the last decade, and while focus has been on treating clinical symptoms, the associated changes in the immune system remains poorly understood. Several key immunological regulators, including Interleukin (IL)-6 are intimately associated with rheumatoid arthritis disease progression. In this proof-of-concept case study we assess the immunological changes in multiple important immune cell populations to treatment with the commonly applied bDMARD tocilizumab, a humanized monoclonal antibody against the IL-6 receptor. Methods: Peripheral blood was obtained from one rheumatoid arthritis patient with poor response to conventional DMARD, before biological treatment and 4 months after. Peripheral blood mononuclear cells were extracted and separated into CD14+, CD4+, CD8+, .. View More»
  DOI: 10.4172/jpb.1000380

  Abstract PDF

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