Journal of Clinical and Cellular Immunology
Open Access
ISSN: 2155-9899
ISSN: 2155-9899
Svetlana A Morozova
Serbia
Research Article
Association Between Alleles of Cytokine Genes with Rheumatoid Arthritis in Russian Population
Author(s): Nataliya E Soroka, Svetlana A Morozova, Valery V Ilinsky, Dmitry Y Trof mov and Denis V RebrikovNataliya E Soroka, Svetlana A Morozova, Valery V Ilinsky, Dmitry Y Trof mov and Denis V Rebrikov
Background: Rheumatoid arthritis (RA) is a multi-factor disease with a key role of genetic component in its genesis. Development of osteoporosis and articular destruction is attributed with overexpression of pro-infl ammatory cytokines and reduced production of anti-infl ammatory ones. In this work probable associations of IFN-γ, IL-1α, IL-1β, IL-4, IL-6, IL-10, IL-18 and TNFα alleles with rheumatoid arthritis were studied among Russian ethnic group. Methods: A total of 69 Russian ethnical group patients with RA (cases) and 133 healthy control individuals (controls) were genotyped for variants in 8 cytokines genes (IFN-γ, IL-1α, IL-1β, IL-4,IL-6, IL-10, IL-18 and TNFα). Individual genotype and haplotype frequencies were compared between cases and controls. Odd ratios were calculated with asymptotic 95% co.. View More»
DOI:
10.4172/2155-9899.1000102