Rheumatology: Current Research
Open Access

Syed Shafiaa

Publications

• Research Article
  Anti-CCP is Associated with Greater Disease Burden in Kashmiri Population with Rheumatoid Arthritis
  Author(s): Syed Shafiaa, Zafar Amin Shaha, Fayaz A Sofib, Roohi Rasoola and Ayaz Gulla Syed Shafiaa, Zafar Amin Shaha, Fayaz A Sofib, Roohi Rasoola and Ayaz Gulla
  
  Aim: To analyse the diagnostic value of anti-cyclic Citrullinated Peptide (anti-CCP) and to associate it with disease severity in patients with rheumatoid arthritis in Kashmiri population. Methods: The serum levels of anti-CCP levels were measured in 150 RA patients and 30 healthy controls by ELISA technique. Result: 118 (78.66%) patients were positive for anti-CCP while none of the healthy controls were positive for the test. The mean ± SD serum anti-CCP levels were significantly (p<0.0001) higher in RA patients than in healthy controls (68.33 ± 42.13 U/mL vs 2.88 ± 1.81 U/mL). The sensitivity and specificity of the test was 78.67% (CI: 71.24-84.93 and 100 % (CI: 88.32-100%) respectively. The PPV and NPV of test for RA diagnosis was 100% (CI: 96.89-100%), and 48.39% (CI: 35.50-61.43%) respe.. View More»
  DOI: 10.4172/2161-1149.1000190

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