Anesthesia & Clinical Research
Open Access

Takayuki Noguchi

Publications

• Case Report
  Sugammadex is Safe and Effective for Patients with Myasthenia Gravis
  Author(s): Chihiro Shingu, Taichi Nishida, Satoshi Hagiwara, Keisuke Shiihara, Yoshimasa Oyama, Takakuni Abe and Takayuki Noguchi Chihiro Shingu, Taichi Nishida, Satoshi Hagiwara, Keisuke Shiihara, Yoshimasa Oyama, Takakuni Abe and Takayuki Noguchi
  
  Thymoma, which can be surgically treated under general anesthesia, is associated with the pathophysiology of myasthenia gravis. Muscle weakness is a hallmark of myasthenia gravis; therefore, these patients are hypersensitive to the effects of nondepolarizing muscle relaxants. Neuromuscular blockers can cause prolonged postoperative muscle relaxation, leading to decreased respiratory function. Therefore, careful administration of muscle relaxants during the perioperative period is important. The neuromuscular antagonist, sugammadex, has been used to counteract problems associated with muscle relaxants. By encapsulating nondepolarizing muscle relaxants, sugammadex can reverse the neuromuscular blockade. Here we report three cases of myasthenia gravis. In each case, perioperative management included use of a train-of-four (TOF) monitor to minimize muscle relaxant use during surgery. Suga.. View More»
  DOI: 10.4172/2155-6148.1000122

  Abstract PDF

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