Translational Medicine
Open Access
ISSN: 2161-1025
ISSN: 2161-1025
Takuya Watanabe
Japan
Review Article
Novel Technologies and Future Perspectives of Drug-Eluting Stent
Author(s): Kohei Wakabayashi, Rajbabu Pakala, Michael Mahmoudi, Takuya Watanabe, Hiroyoshi Mori, Yoshitaka Iso and Hiroshi Suzuki Kohei Wakabayashi, Rajbabu Pakala, Michael Mahmoudi, Takuya Watanabe, Hiroyoshi Mori, Yoshitaka Iso and Hiroshi Suzuki
As compared with bare metal stents (BMS), Drug-eluting stents (DES) have dramatically reduced the incidence of target lesion revascularization and neointimal formation. There are, however, potential toxic effects of DES upon arterial tissue. Previous pathological studies have indicated that durable polymers and the drug itself play critical role in delayed endothelialization, persistent inflammation, hypersensitivity, apoptosis, necrosis, and positive remodeling leading to adverse cardiovascular events. To address these issues, new generation DES, biodegradable polymers, polymer-free and fully bioabsorbable scaffolds are currently in evolution. This review summarized the clinical trials that have assessed the feasibility and efficacy of new generation DES. A number of pivotal trials have also demonstrated the non-inferiority of biodegradable polymer or polymer-free DES to durable poly.. View More»
DOI:
10.4172/2161-1025.S7-002