Medicinal & Aromatic Plants
Open Access

Tamara C Lopes de Castro

Publications

• Research Article
  Extramedular Hematopoiesis in the Spleen of Obese Mice Modulation by the Alga Chlorella
  Author(s): Cristiane O Torello, Edgar J Paredes-Gamero, Fernanda Martins, Tamara C Lopes de Castro, Mario JA Saad, Sara TO Saad, Claudia Bincoletto and Mary LS Queiroz Cristiane O Torello, Edgar J Paredes-Gamero, Fernanda Martins, Tamara C Lopes de Castro, Mario JA Saad, Sara TO Saad, Claudia Bincoletto and Mary LS Queiroz
  
  In this study, Balb/C mice received standard or high-fat diet (HFD) and were treated with Chlorella for 5 days prior and 4 weeks after the onset of HFD. Our findings demonstrate that in HFD-induced obesity, there is a rapid decline in the number of granulocyte and macrophage progenitors (CFU-GM) in the bone marrow, which is associated with a continuous migration/increase of these cells into the spleen, a process characterized as extramedullary hematopoiesis (EMH). No changes in the size of the primitive (LSK), and reduction in the size of the granulocyte/macrophage (GMP) hematopoietic populations in the bone marrow were observed. We also found that increased expression of C-C chemokine receptor type 2 (CCR2) on GMP in the spleen might be a mechanism related to the migration of CFU-GM to this organ. Increased serum colony-stimulating activity (CSA) was also found in obese mice.. View More»
  DOI: 10.4172/2167-0412.1000275

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