Immunotherapy: Open Access
Open Access

Teiti Iotefa

Publications

• Research Article
  Atorvastatin-Induced Inhibition of Human Melanoma In Vivo Development
  Author(s): Teiti Iotefa, Sarrabayrouse Guillaume, Filali Liza, Maisongrosse Véronique, Rochaix Philippe and Tilkin-Mariamé Anne-Françoise Teiti Iotefa, Sarrabayrouse Guillaume, Filali Liza, Maisongrosse Véronique, Rochaix Philippe and Tilkin-Mariamé Anne-Françoise
  
  Statins, 3-hydroxy 3-methylglutaryl CoA (HMG-CoA) reductase inhibitors, are pleiotropic pharmacological inhibitors, which block the mevalonate synthesis pathway. They are widely used as hypocholesterolemic agents and have shown protective effects against cancers. Our previous data showed that statin treatment induced MHC class I chain-related protein A (MICA) membrane overexpression in human melanoma cells, which increased their sensitivity to NK cell cytotoxicity and thus the inhibition of tumor development. MICA is a ligand of the NK cell activating receptor NKG2D. This receptor is essential for NK cell control of tumor development and it has the unique property of being able to recognize tumor cells of both murine and human origin. Here, using atorvastatin and the WM-266-4 melanoma cell line, we first confirmed that statin treatment enhances MICA membrane expres.. View More»
  DOI: 10.4172/2471-9552.1000111

  Abstract PDF

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