Journal of Clinical & Experimental Dermatology Research
Open Access

Temitope. O. Lawal

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• Research
  Anti-Dermatophytic Potential of Formulated Extract of Cola nitida (Vent.) Schott& Endl. (Stem Bark)
  Author(s): Olakunle O. Mebude, Temitope. O. Lawal and Bola A. Adeniyi Olakunle O. Mebude, Temitope. O. Lawal and Bola A. Adeniyi
  
  The antifungal activities of stem bark ethanolic extract of Cola nitida [Vent.) Schott & Endl. against fungi associated with dermatophytes was determined in vitro by agar cup diffusion, agar dilution technique, and time kill assay. The result showed that the extract at concentrations ranging between 6 mg/mL to 0.5 mg/mL produced zone of inhibition between 10 ± 0.1 and 25 ± 0.2 mm against the test fungi. The MIC and MFC of the extract ranged from 22.5 to 3120 µg/mL and 45 to 3120 µg/mL respectively. The MICs for Trichophyton rubrum and T. tonsurans were less than 100 µg/mL and the mechanism of antibiosis indicated that the formulated ethanolic extract was highly fungicidal.  Since lower MIC and MFC indicates higher efficacy, the MIC/MFC in this study are within the range of ≤ 100 and ≥ 1000 µg/mL. .. View More»
  DOI: 10.4172/2155-9554.1000394

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