Journal of Drug Metabolism & Toxicology
Open Access

Tetsuto Nagata

Publications

• Research Article
  Absorption, Distribution and Excretion Pattern of Oral and Transdermal Donepezil Hydrochloride after Single and Repeated Administration to the Rat
  Author(s): Susan R. Meier-Davis, Marie-Eve Rodrigue, Masahiro Yamaji, Yoshiko Katori-Stowell, Jianye Wen, Fatima M. Arjmand, Jutaro Shudo and Tetsuto Nagata Susan R. Meier-Davis, Marie-Eve Rodrigue, Masahiro Yamaji, Yoshiko Katori-Stowell, Jianye Wen, Fatima M. Arjmand, Jutaro Shudo and Tetsuto Nagata
  
  Donepezil hydrochloride formulated in a transdermal patch for weekly administration is an alternative to the approved daily oral tablet. Transdermal delivery has a locally high concentration at the application site causing potential safety issues. To assess the skin exposure for safety evaluation, studies were performed comparing the donepezil transdermal patch with an oral donepezil dose previously tested in a carcinogenicity study, in which no test article-induced tumors were found. Quantitative Whole Body Autoradiography (QWBA) comparison in Long-Evans rats administered 14C-donepezil either as single oral dose (30 mg/kg) or a 24-hour transdermal patch (~60 mg/kg) revealed similar organ distribution, including skin. Pigmented tissue, namely, skin and eye showed sustained labeling over 7-10 days, suggesting melanin binding. Subsequently, a 14C-donepezil study .. View More»
  DOI: 10.4172/2157-7609.1000123

  Abstract PDF

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