Journal of Clinical and Cellular Immunology
Open Access

Thomas M. Yankee

Publications

• Commentary
  The Role of the Ikaros Family of Transcription Factors in Regulatory T cell Development and Function
  Author(s): Amara Seng and Thomas M. Yankee Amara Seng and Thomas M. Yankee
  
  Regulatory T (Treg) cells are a subset of immune cells that maintain homeostasis by promoting immune tolerance and suppressing the immune response via a variety of mechanisms such as secreting cytokines, killing reactive immune cells, and inducing anergy. Dysfunction of Treg cells has been implicated in inflammatory diseases such as autoimmunity and transplant rejection. Conversely, too many or hyperresponsive Treg cells has been observed in cancer and chronic infections. Treg cells have proven to be difficult to study as there are no definitive Treg surface markers. Additionally, Tregs can gain pro-inflammatory phenotype depending on stimuli. In this commentary, we discuss the expression and function of members of the Ikaros family of transcription factors during Treg cell development and activation. .. View More»
  DOI: 10.4172/2155-9899.1000495

  Abstract PDF

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