Journal of Clinical & Experimental Dermatology Research
Open Access

Thomas Ruzicka

Publications

• Research Article
  VEGF Induces IL-23 Expression in Keratinocytes through p38 Signaling
  Author(s): Miriam Canavese, Mark Peric, Yvonne Dombrowski, Sarah Koglin, Thomas Ruzicka and Jürgen SchauberMiriam Canavese, Mark Peric, Yvonne Dombrowski, Sarah Koglin, Thomas Ruzicka and Jürgen Schauber
  
  Background: Psoriasis is a chronic inflammatory skin disorder which is associated with increased cutaneous vascular endothelial growth factor (VEGF) expression. Several studies demonstrate that VEGF plays an important role in psoriasis pathogenesis by linking angiogenesis and inflammation. We aimed to study the molecular functions of VEGF in psoriasis and dissect a link between VEGF and pro-inflammatory cytokine expression in human keratinocytes. Methods: VEGF expression was evaluated in sections from lesional psoriatic skin by immunohistochemistry. Cultured keratinocytes were transfected with a VEGF expression plasmid and changes in pro-inflammatory cytokine expression were investigated by qPCR, ELISA and dot-blot. Protein phosphorylation profiles in lysates from cells overexpressing VEGF were analysed to identify the underlying signaling pathw.. View More»
  DOI: 10.4172/2155-9554.S2-002

  Abstract PDF

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