Chemotherapy: Open Access
Open Access
ISSN: 2167-7700
ISSN: 2167-7700
Tianhong Su
Indiana
Research Article
The Effect of Metformin on Colorectal Carcinoma in Type 2 Diabetes
Mellitus Patients: A Markov Model Analysis
Author(s): Tianhong Su, Yihao Liu, Weifeng Liu, Shuling Chen, Qian Zhou, Zhenwei Peng, Sui Peng and Haipeng Xiao
Tianhong Su, Yihao Liu, Weifeng Liu, Shuling Chen, Qian Zhou, Zhenwei Peng, Sui Peng and Haipeng Xiao
Objective: Morbidity and mortality of colorectal cancer (CRC) in type 2 diabetes mellitus (T2DM) patients are higher than that of general population, the mechanism of which remains undetermined. Some studies found that metformin could lower the risk of cancer, including CRC, in T2DM patients, but others demonstrated different results. Therefore, we target to evaluate the CRC prevention effect of metformin in comparison with that of other T2DM medications from a Markov model perspective.
Methods: A Markov model simulating a randomized trial comparing metformin with non-metformin treatment in T2DM patients without CRC over 11-year time horizon was constructed based on data from 8 literatures. CRC morbidity was selected as endpoint. Monte Carlo analysis with 10,000 patients allocated for each arm was performed to assess CRC morbidity and cumula.. View More»
DOI:
10.4172/2167-7700.1000233