Journal of Leukemia
Open Access

Timothy J. Brown

Publications

• Research Article
  Combinatorial Efficacy of Nanoliposomal Ceramide and the Antioxidant 7,8- Benzoflavone for Acute Myeloid Leukemia
  Author(s): Brian M. Barth, Timothy J. Brown, Matthew T. Adams, Aileen M. Garcia, Lindsey N. Fisher, Jennifer L. Fritz, Adam J. Beck, Colin M. McGill, Mark Kester, Melissa A. Tran and David F. Claxton Brian M. Barth, Timothy J. Brown, Matthew T. Adams, Aileen M. Garcia, Lindsey N. Fisher, Jennifer L. Fritz, Adam J. Beck, Colin M. McGill, Mark Kester, Melissa A. Tran and David F. Claxton
  
  Ceramide-based therapeutics have gained recent attention as anti-neoplastic therapeutics. These include standard of care therapeutics that in part exert efficacy through the generation of ceramide, as well as new therapeutics that seek to specifically deliver or augment ceramide levels in malignant cells. Ceramide is a bioactive sphingolipid involved in apoptotic and stress cellular signaling pathways. It has also been shown to regulate oxidative stress, which may negate its otherwise anti-neoplastic effects by promoting the proliferation of leukemia cells. Metabolism of ceramide to neutral or pro-oncogenic metabolites can serve as a further pathway of therapeutic resistance. In this study, the antioxidant 7,8-benzoflavone (BF) was identified through a natural products chemical library screening process as a compound that can augment the efficacy of nanoliposomal C6-ceramide (Lip-C6) in .. View More»
  DOI: 10.4172/2329-6917.1000152

  Abstract PDF

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